I was sympathetic to you regarding the situation you are in.
Well you said your wife is highly educated, caring and helpful only when it comes to her own immediately family but is bewildered when it is about your side of family.
There are so many aspects of this issue. That arise so many question in mind;
Was this her attitude from the day one?
If so what was done to bring her closer?
What was the attitude of your family towards her from the day one?
Did their behavior made her adopt this tone?
Is your family too highly educated compatibly to her? ( although this is not necessary though but some time becomes an issue)
Does she give every due respect to her own parents and mostly listen to them or mostly trust her own decisions?
Is she religious and hold respect for family value?
I mean is she an obedient daughter?
Is she religious?
If it is from the beginning without any obvious reason it might be that she is scared of the myth of this relation by default. You know people , specially women folks create a fear and hatered in the minds of young girls unknowingly from thier child hoof creatig and image of aglaa gher or susraal a jail and the MILs as the supreme jailer.
Or she may be just very possessive about you.

As learned as she is she is in a position to better understand such situations as his seeking worldly knowledge can also enlighten a person. It gives a person an inner vision to resolve the things.
I think you and only you could have played a very strong part to bring her closer to your family. Initially. Had she known from the day one the value of your parents and family you hold, she;for your sake would have given them some space in her heart. But if you had taken their connection in your life for granted how would she show any connection?
It is your duty as a son to make her intimate and make her love your parents,in spacial and brothers,sisters in general.
I hope it is not too late. But it should only be done with love and patience.
Remember while dealing with an educated person that education when used wrongly by an individual is the worst kind of disaster.
May God Help you.Amen
wassalam